With LSC = 0.031 g/cm², is a change from 0.632 to 0.598 g/cm² significant?

• A. No, it is not significant
• B. Yes, it is significant
• C. It depends on the context of the scan
• D. It is significant only if a specific threshold is met

Answer: (B)

To determine if a change in bone mineral density (BMD) values, from 0.632 g/cm² to 0.598 g/cm², is significant, it is essential to consider the Least Significant Change (LSC). In this case, the LSC is given as 0.031 g/cm².

The significance of a change in BMD is often assessed by comparing the absolute difference between the two readings to the LSC. The difference between the two values in this scenario is calculated as follows:

0.632 g/cm² - 0.598 g/cm² = 0.034 g/cm².

This difference of 0.034 g/cm² exceeds the LSC of 0.031 g/cm². When a change exceeds the LSC, it indicates that the difference is not likely due to random fluctuations or measurement error, suggesting that it is statistically significant. Such a finding is important in clinical practice as it might indicate a meaningful change in the patient's bone density status, which could have implications for diagnosis and treatment decisions.

In summary, since the observed change in BMD exceeds the LSC, it indicates that this change is significant.