What does LSC stand for in the context of DXA measurements?

• A. Lowest Significant Change
• B. Least Significant Change
• C. Limit of Significant Change
• D. Lowest Sensitivity Change

Answer: (A)

The correct choice refers to "Lowest Significant Change," which is a critical concept in the analysis of bone densitometry results. In the context of Dual-energy X-ray Absorptiometry (DXA) measurements, LSC provides a valuable metric for determining whether a change in bone mineral density (BMD) between two scans is statistically significant or could be attributed to normal variations in the measurement process.

Understanding LSC is essential for clinicians and operators because it establishes a threshold for interpreting changes in BMD over time. If a change in a patient's results exceeds the LSC, it suggests that the change is likely indicative of a true alteration in bone density rather than an artifact of measurement error or biological variability.

The other options incorrectly frame the term or introduce variations on the concept that do not align with the established terminology used in the field. For instance, while "Least Significant Change" might be intuitively similar, it does not reflect the correct terminology utilized in scientific literature and clinical practice regarding DXA scans.