What does a low 1/3-radius T-score below -2.5 indicate regarding fracture risk?

• A. Fracture risk is solely elevated at the forearm.
• B. Systemic fracture risk is still elevated, not just at the forearm.
• C. Fracture risk is normal.
• D. Fracture risk is elevated only at the spine.

Answer: (B)

A low 1/3-radius T-score below -2.5 is significant because it indicates a lower bone density in the distal radius, a common site for assessing bone health. This specific T-score suggests that the individual has osteoporosis, which is classified by the World Health Organization as having a T-score of -2.5 or lower.

When the bone density is low, it does not just imply that the risk of fracture is elevated at that particular site (the forearm), but it indicates a more systemic issue. Osteoporosis tends to affect the skeleton as a whole, meaning that the individual is at increased risk for fractures not just in the forearm, but also in other areas including the spine and hip. The presence of a low T-score at the 1/3-radius signifies that the overall bone quality and density are compromised, which in turn raises the risk for fractures throughout the body.

This systemic risk is critical for clinical management and treatment of patients, as it necessitates a comprehensive approach to address bone health beyond localized concerns.